Hybrid glycophorins: Silent genetic variants complicate genetic testing

Testing genetic association with rare variants in admixed populations.

Recent studies suggest that rare variants play an important role in the etiology of many traits. Although a number of methods have been developed for genetic association analysis of rare variants, they all assume a relatively homogeneous population under study. Such an assumption may not be valid for samples collected from admixed populations such as African Americans and Hispanic Americans as ...

Testing of Hybrid Genetic Algorithms for Structured Quadratic Assignment Problems

In this paper, an efficient hybrid genetic algorithm (HGA) and its variants for the wellknown combinatorial optimization problem, the quadratic assignment problem (QAP) are discussed. In particular, we tested our algorithms on a special type of QAPs, the structured quadratic assignment problems. The results from the computational experiments on this class of problems demonstrate that HGAs allow...

Genetic testing, genetic medicine, and managed care.

As modern human genetics moves from the research setting to the clinical setting, it will encounter the managed care system. Issues of cost, access, and quality of care will affect the availability and nature of genetic testing, genetic counseling, and genetic therapies. This Article will explore such issues as professional education, coverage of genetic services, privacy and confidentiality, a...

Genetic Variants of Γg4 Globulin

Two types of gammaG4 proteins, termed 4a and 4b, were characterized through antigenic studies of myeloma proteins. Both were recognized by specific antigens on the Fc fragment which were shared with other gammaG classes. The distinctive antigen of the common 4a type was shared with all gammaG1 and gammaG3 proteins but missing in those of the gammaG2 class; that for the rarer 4b type was selecti...

Modeling Hybrid Genetic Algorithms